Le mveliso inempembelelo enamandla yokuthintela kwiibhaktheriya ezininzi zegram-positive kunye ne-negative. Iibhaktheriya ezithintekayo kwiziyobisi ze-sulfonamide azikwazi ukusebenzisa i-folic acid kwindawo engqongileyo, ingasebenzisa kuphela i-p-aminobenzoic acid kunye ne-dihydropteridine, phantsi kwesenzo se-bacterial dihydrofolate synthase ukuze idibanise i-tetrahydrofolate, i-tetrahydrofolate esebenzayo kwi-synthesis ye-purine, i-thymine nucleoside idlala indima ebalulekileyo ekudlulisweni kwekhabhoni yeqela. Amachiza e-sulfa afana nesakhiwo kwi-p-aminobenzoic acid, kwaye angakwazi ukukhuphisana ne-p-aminobenzoic acid ye-dihydrofolate synthetase kwiibhaktheriya, athintele ukuhlanganiswa kwe-dihydrofolate, ekugqibeleni achaphazele ukuhlanganiswa kwe-nucleic acid, kwaye athintele ukukhula kunye nokuveliswa kwebhaktheriya. Isenzo samachiza esulfanilamide sinokuchaswa ngamachiza anokugaya i-amino benzoic acid, njengeprocaine netetracaine. Ukongeza, ubovu kunye neemveliso zokuqhekeka kwezicubu zinokubonelela ngezinto eziyimfuneko ekukhuleni kwebhaktheriya, kwaye zibe neziphumo ezichasayo kwi-sulfonamides. I-Trimethoprim yi-synergist ye-antibacterial evimbela umsebenzi we-dihydrofolate reductase. Ukudibanisa kwezi zibini kunokuvelisa umphumo we-synergistic ukunyusa umphumo we-antibacterial.
I-sulfonamides antibacterial drugs, uninzi lweebhaktheriya ezinegram-positive kunye neebhaktheriya ezingalunganga zinempembelelo enamandla yokuthintela, esetyenziswa kwimfuyo kunye neenkukhu escherichia coli kunye nosulelo lwe-pasteurella. Isenokusetyenziswa kwihagu toxoplasmosis, iinkukhu kunye nomvundla coccidiosis.
Ngale mveliso. Kulawulo lwangaphakathi: Idosi yemihla ngemihla, nge-1kg ubunzima bomzimba, i-32mg yehagu kunye nenkukhu; kwiihagu, kangangeentsuku ezi-5 ukuya kwezili-10; kunye nenkukhu, iintsuku ezi-3 ukuya kwezi-6. Ukutya okuxutyiweyo: Le mveliso 100g mix 500 ~ 750kg, ukusetyenziswa okuqhubekayo kwehagu 5 ~ 10 iintsuku, ukusetyenziswa okuqhubekayo kwenkukhu 3 ~ 6 iintsuku. Isiselo esixutyiweyo: 100g yale mveliso ixutywe namanzi 1000- 1500kg, isetyenziselwa iintsuku ezi-5 ~ 10 kwiihagu, 3 ~ 6 iintsuku kwiinkukhu.
