I-Pharmacodynamics enrofloxacin liyeza elibanzi le-bactericidal yezilwanyana ze-fluoroquinolone. Inefuthe elihle kwi-escherichia coli, i-salmonella, i-klebsiella, i-brucella, i-pasteurella, i-actinobacillus pleuropneumoniae, i-erysipelas, i-proteus, i-serratia marcescens, i-corynebacterium pyogenes, i-portococcus septicus, i-staphylococcus aureus, i-mycoplasma, i-mycoplasma, njl njl. i-aeruginosa kunye ne-streptococcus, kunye nefuthe elibuthathaka kwibhaktheriya ye-anaerobic. Inesiphumo esicacileyo se-post-antibacterial kwiibhaktheriya ezibuthathaka. Indlela yokulwa ne-antibacterial yale mveliso kukuthintela i-enzyme yokujikeleza kwe-bacterial dna, ukuphazamisa ukuphindaphinda kwe-bacterial dna, ukushicilelwa kunye nokulungiswa kwakhona, iibhaktheriya azikwazi ukukhula kwaye zivelise ngokuqhelekileyo kwaye zife.
I-Pharmacokinetics i-intramuscular absorption yale mveliso ikhawuleza kwaye iphelele, kunye ne-bioavailability ye-91.9% kwiihagu kunye ne-82% kwiinkomo zobisi. Isasazwa ngokubanzi kwizilwanyana kwaye inokungena kwizicubu kunye namanzi omzimba kakuhle, ngaphandle kwe-cerebrospinal fluid, ukuxinwa kweziyobisi phantse kuzo zonke izicubu ziphezulu kune-plasma. I-metabolism yesibindi ikakhulu ukuvelisa i-ciprofloxacin ngokususa i-ethyl ye-7-piperazine ring, ilandelwa yi-oxidation kunye ne-glucuronic acid yokubopha. Ininzi ikhutshwe yizintso (nge-renal tubule secretion kunye ne-glomerular filtration), kwaye i-15% ukuya kwi-50% ikhutshwe kumchamo kwimo yayo yangaphambili. Ukupheliswa kobomi besiqingatha kuyahluka kakhulu kwiintlobo ezahlukeneyo kunye neendlela ezahlukeneyo zolawulo. Ukuphelisa isiqingatha sobomi emva kokutofwa nge-intramuscular yi-5.9 iiyure ezinkomeni, iiyure eziyi-9.9 emahasheni, iiyure eziyi-1.5 ukuya kwezi-4.5 kwiigusha, kunye neeyure ezi-4.6 kwiihagu.
1. Le mveliso inefuthe le-synergistic xa isetyenziswe kunye ne-aminoglycoside okanye i-penicillin ebanzi.
2. Ionini zetsimbi ezinzima ezifana ne-ca2 +, mg2 +, fe3 + kunye ne-al3 + i-canchelate kunye nale mveliso kwaye ichaphazela ukufunxa.
3. Xa zidityaniswe ne-theophylline kunye ne-caffeine, inokunciphisa izinga lokubopha kwiprotheni ye-plasma, ikhulise ngokungaqhelekanga i-theophylline kunye ne-caffeine egazini, kwaye ibonakale iimpawu zetyhefu ye-theophylline.
4. Le mveliso inefuthe lokuthintela i-enzymes yeziyobisi zesibindi, ezinokunciphisa izinga lokucocwa kweziyobisi ezixutywe kakhulu kwisibindi kunye nokwandisa uxinzelelo lwegazi.
I-Fluoroquinolone antibacterial drugs. Isetyenziselwa imfuyo kunye neenkukhu izifo zebhaktheriya kunye nosulelo lwe-mycoplasma.
Inaliti ye-Intramuscular: Idosi enye, i-0.025ml nge-1kg yobunzima bomzimba weenkomo, iigusha kunye neehagu; 0.025 ~ 0.05ml izinja, iikati kunye nemivundla. Sebenzisa i-1 ukuya ku-2 amaxesha ngosuku ngeentsuku ezi-2 ukuya kwezi-3.
1. I-Cartilage degeneration kwizilwanyana ezincinci, ezichaphazela ukuphuhliswa kwamathambo kunye nokubangela ukuqhwala kunye neentlungu.
2. Ukusabela kwenkqubo yokugaya kubandakanya ukuhlanza, ukulahlekelwa ngumdla, isifo sohudo kwaye ngokukhawuleza.
3. Ukuphendula kwesikhumba kubandakanya i-erythema, pruritus, urticaria kunye ne-photosensitivity.
4. Ukuxhatshazwa, i-ataxia, i-seizures ibonakala kwizinja kunye neekati.
1. Inempembelelo enokubakho yokuvuselela inkqubo ephakathi, ibangela ukuba i-epileptic seizures, kwaye kufuneka isetyenziswe ngokuqaphela kwizinja ze-epileptic.
2. Izilwanyana ezidla inyama kunye nezilwanyana ezinokungasebenzi kakuhle kwezintso kufuneka zisetyenziswe ngononophelo, ezinokuthi ngamanye amaxesha zibangele umchamo oyikristale.
3. Le mveliso ayifanelekanga kumahashe. Iinaliti ze-Intramuscular zicaphukisa okwethutyana.
4. Le mveliso akufanele isetyenziswe kwizinja ngaphambi kweeveki ezi-8 ubudala.
5. Iintlobo ezixhathisa ichiza zale mveliso ziyanda kwaye akufanele zisetyenziswe kwiidosi ze-subtherapeutic ixesha elide.
