I-10% yesitofu se-Iron Dextran

I-iron ye-Pharmacodynamic iyona nxalenye ephambili ye-hemoglobin kunye ne-myoglobin. IHemoglobin yeyona nto ithwala ioksijini kwiiseli ezibomvu zegazi. I-Myoglobin kulapho iiseli zezihlunu zigcina ioksijini ukunceda ukubonelela izihlunu ngexesha lokuzilolonga. Uninzi lwee-enzymes kunye nezinto ezibandakanyekayo kumjikelezo we-tricarboxylic acid ziqulethe isinyithi okanye umsebenzi kuphela xa kukho isinyithi. Ke ngoko, ukongeza kwi-hemoglobin synthesis ekhawulezileyo, iimpawu ezinxulumene nokunqongophala kwe-iron kunye nokuncipha komsebenzi wee-enzymes ezine-iron, ezinje ngokuncipha kokukhula, iziphako zokuziphatha, kunye nokusilela komzimba, zinokulungiswa ngokuthe ngcembe emva kokufakwa kwentsimbi esebenzayo kwizilwanyana eziswele intsimbi. Intsimbi ye-Pharmacokinetic ye-injection ifakwe ngokukhawuleza kunentsimbi yomlomo; emva kokutofa nge-intramuscular of iron dextran, umlinganiselo wegazi wafikelela incopho yawo kwiiyure ezingama-24-48, kwaye imolekyuli yayo yayinkulu. Yaxutywa yimithambo ye-lymphatic kwaye emva koko idluliselwe egazini, kwaye ukuxinwa kwegazi kwanda kancinci; emva kokufakwa kwi-intravenous okanye intramuscular injection kwi-circulation yegazi, i-phagocytic kwaye ihlanjululwe ibe yintsimbi kunye ne-dextran nge-mononuclear phagocytic cell system. Emva kokufunxwa, ii-ion zentsimbi zixutywa kwi-ion ye-ferric nge-ceruloplasmin egazini, kwaye emva koko zibophe kwi-receptors ye-transferrin, faka iiseli ngendlela ye-pinocytosis yeeseli ze-hematopoietic, okanye ziqokelele ngendlela ye-ferritin okanye i-hemosiderin kwisibindi, udaka, umongo wethambo kunye nezinye iinkqubo zeseli ye-mononuclear. Izinga lokubopha iprotheni liphezulu kwi-hemoglobin, kodwa liphantsi kwi-myoglobin, i-enzymes kunye neeprotheni zokuthutha isinyithi, kunye ne-ferritin ephantsi okanye i-hemosiderin.