I-Pharmacodynamic lincomycin yeye-lincoamine antibiotics, i-agent ye-bacteriostatic, iibhaktheriya ezibuthathaka ziquka i-staphylococcus aureus (kubandakanywa ne-penicillin-resistant strains), i-streptococcus, i-pneumococcus, i-bacillus anthracis, i-erysipelas suis, enye i-mycoplasma (mycoplasmaissal mycoplasma, mycoplasma, mycoplasma synovialis), i-leptospirosis kunye neebhaktheriya ze-anaerobic (ezifana ne-clostridium difficile, i-clostridium tetanus, i-clostridium percapsulatus kunye ne-actinomyces eninzi). Isebenza kakhulu kwi-50s subunit ye-ribosome yebhaktiriya, kwaye yenza i-antibacterial effect ngokuthintela ukwandiswa kwekhonkco le-peptide kunye nokuchaphazela i-protein synthesis.
Ukuxutywa kwakhawuleza emva kwe-injection ye-intramuscular, kunye ne-injection eyodwa ye-intramuscular ye-11mg / kg kwiingulube kunye ne-peak concentration yegazi ye-6.25μg / ml. Izinga lokubopha iprotheyini yeplasma yayingama-57% - 72%. Isasazwa ngokubanzi kwi-vivo, kunye nomthamo obonakalayo wokuhanjiswa kwe-2.8 l / kg kwiihagu. Isasazwa ngokubanzi kumanzi ahlukeneyo omzimba kunye nezicubu (kubandakanya ithambo), apho ukuxinana kwesibindi kunye nezintso yeyona iphakamileyo, kwaye ukuxinana kwechiza kwezicubu kuphezulu ngokuphindwe kaninzi kuneserum ngexesha elinye. Inokungena kwi-placenta, kodwa akukho lula ukungena kumqobo we-blood-brain barrier, kwaye kunzima ukufikelela kugxininiso olusebenzayo lweyeza kwi-cerebrospinal fluid xa ukudumba kwenzeka. Inokusasazwa ebisini, kwaye ukugxininiswa kobisi kuyafana naleyo kwiplasma. Inxalenye yeziyobisi i-metabolized esibindini, kwaye ifom yeziyobisi kunye ne-metabolites yayo ikhutshwe nge-bile, umchamo kunye nobisi. Ukukhupha kwi-stool kunokulibaziseka iintsuku ezininzi, ngoko kunempembelelo yokuthintela kwii-microorganisms ezibuthathaka zamathumbu.
1. Xa idibene ne-gentamicin, inefuthe le-synergistic kwiibhaktheriya zegram-positive ezifana ne-staphylococcus kunye ne-streptococcus.
2. Xa idibene ne-aminoglycosides kunye ne-polypeptide antibiotics, inokuphucula umphumo wokuthintela kwi-neuromuscular junction. Idityaniswe ne-erythromycin inefuthe elichasayo, kuba indawo yesenzo iyafana, kwaye i-erythromycin inobudlelwane obunamandla kwi-50s subunit ye-ribosomes yebhaktiriya kunale mveliso.
3. Akufanele idibaniswe neziyobisi ezichasene ne-antidiarrheal ezivimbela i-intestinal peristalsis kwaye iqulethe udongwe olumhlophe. 4. Kukho ukungahambelani nekanamycin, neomycin, njl.
I-Lincoamine antibiotics. Usulelo lwe-bacteria yegram-positive, ingasetyenziselwa i-treponemosis kunye ne-mycoplasma kunye nezinye izifo.
Inaliti ye-Intramuscular: Idosi enye, 0.0165 ~ 0.033ml nge-1kg yobunzima bomzimba kumahashe kunye neenkomo, i-0.033ml yeegusha neehagu, kanye ngemini; I-0.033ml yezinja kunye neekati, kabini ngosuku, iintsuku ezi-3 ukuya kwezi-5.
Inaliti ye-Intramuscular inokubangela urhudo okwethutyana okanye ilindle elithambileyo. Nangona kunqabile, amanyathelo ayimfuneko kufuneka athathwe ukukhusela ukuphelelwa ngamanzi emzimbeni ukuba kwenzeka.
